[Hematopoietic stem cell transplant in combined immunodeficiency syndromes of childhood: an optimal treatment for primary immunodeficiency]
| Autor: | Alberto, Olaya-Vargas, Rocío, Coronel-Moran, Roberto, Rivera-Luna, Amalia, Bravo-Lindoro, Yadira, Bejar-Ramírez, Doris, Lormendez-Jacome |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Fetal Therapies Adolescent Hematopoietic Stem Cell Transplantation Thymus Gland Risk Assessment Transplantation Autologous Lymphocyte Depletion Tissue Donors Liver Transplantation Wiskott-Aldrich Syndrome Fetal Diseases Chorionic Villi Sampling Fetal Tissue Transplantation Child Preschool Histocompatibility Neoplasms Humans Transplantation Homologous Female Severe Combined Immunodeficiency Cord Blood Stem Cell Transplantation Child |
| Zdroj: | Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. 57(2) |
| ISSN: | 0034-8376 |
| Popis: | The congenital immunodeficiency disorders in which the defect has been clearly traced to the stem cell can be cured with allogeneic stem-cell transplantation (SCT) from an unaffected donor. Widespread application of this treatment modality has been tempered by the fact that risk-benefit considerations do not always favor a procedure that carries a significant risk for morbidity and mortality. Some malignant disorders of childhood eventually have to be treated by an autologous or allogeneic SCT, however nonmalignant disorders can also be treated with this approach. This article reviews the current status of SCT for nonmalignant inherited immunodeficiency disorders. |
| Databáze: | OpenAIRE |
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