| Autor: |
Hyun Ji, Noh, Jason, Turner-Maier, S Anne, Schulberg, Michael L, Fitzgerald, Jeremy, Johnson, Kaitlin N, Allen, Luis A, Hückstädt, Annabelle J, Batten, Jessica, Alfoldi, Daniel P, Costa, Elinor K, Karlsson, Warren M, Zapol, Emmanuel S, Buys, Kerstin, Lindblad-Toh, Allyson G, Hindle |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Communications biology. 5(1) |
| ISSN: |
2399-3642 |
| Popis: |
The Weddell seal (Leptonychotes weddellii) thrives in its extreme Antarctic environment. We generated the Weddell seal genome assembly and a high-quality annotation to investigate genome-wide evolutionary pressures that underlie its phenotype and to study genes implicated in hypoxia tolerance and a lipid-based metabolism. Genome-wide analyses included gene family expansion/contraction, positive selection, and diverged sequence (acceleration) compared to other placental mammals, identifying selection in coding and non-coding sequence in five pathways that may shape cardiovascular phenotype. Lipid metabolism as well as hypoxia genes contained more accelerated regions in the Weddell seal compared to genomic background. Top-significant genes were SUMO2 and EP300; both regulate hypoxia inducible factor signaling. Liver expression of four genes with the strongest acceleration signals differ between Weddell seals and a terrestrial mammal, sheep. We also report a high-density lipoprotein-like particle in Weddell seal serum not present in other mammals, including the shallow-diving harbor seal. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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