A cluster of meningococcal disease on a school bus following epidemic influenza

Autor: L H, Harrison, C W, Armstrong, S R, Jenkins, M W, Harmon, G W, Ajello, G B, Miller, C V, Broome
Rok vydání: 1991
Předmět:
Zdroj: Archives of internal medicine. 151(5)
ISSN: 0003-9926
Popis: An outbreak of meningococcal disease among children on a school bus offered the opportunity to study a proposed association between this infection and preceding influenza infection. Five students who rode the bus became ill with invasive group C meningococcus. Transmission was limited to the bus; there was no evidence for school transmission. All five students reported influenza-like symptoms within several weeks before the development of meningococcal disease. School absenteeism, principally due to upper respiratory tract illness, was higher during the 3 weeks before the outbreak of meningococcal disease than during any period in the preceding 3 1/2 years, suggesting an unusually severe outbreak of respiratory illness. A case-control study comparing students with and without influenza symptoms revealed that the outbreak of respiratory disease was due to B/Ann Arbor/1/86 influenza (geometric mean titers, 86 for 80 patients and 33 for 47 controls [P = .0007]). These data add to the evidence suggesting that influenza respiratory infection predisposes to meningococcal disease.
Databáze: OpenAIRE