Analysis of the role of v-rel in transcriptional regulation of high mobility group 14
| Autor: | A K, Walker, P J, Enrietto |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Cell Extracts
Oncogene Proteins v-rel Transcription Genetic Polyunsaturated Alkamides Recombinant Fusion Proteins Molecular Sequence Data Retroviridae Proteins Oncogenic Chick Embryo Bone Marrow Animals Humans Promoter Regions Genetic Conserved Sequence Cell Line Transformed Binding Sites Base Sequence Estradiol Estrogen Antagonists High Mobility Group Proteins NF-kappa B Cell Differentiation Estrogens Fibroblasts Gene Expression Regulation Neoplastic Cell Transformation Neoplastic Receptors Estrogen Cell Division |
| Zdroj: | Oncogene. 12(12) |
| ISSN: | 0950-9232 |
| Popis: | The oncogene, v-rel is a member of the rel/NF-kappaB family of transcription factors. It causes a rapidly fatal lymphoma in young chicks and is capable of transforming both fibroblasts and primitive hematopoietic cells in culture. To understand the role of v-rel in transformation we constructed an inducible form of v-rel and used it to identify potential cellular target genes for v-rel regulation. In this paper we show that High Mobility Group Protein 14 (HMG 14) is expressed in a wide variety of v-rel transformed cell types. In addition we show that v-rel participates in the transcriptional regulation of HMG 14 and that extracts from v-relER cells interact with the HMG 14 promoter. These experiments suggest a role for v-rel in the regulation of a unique gene whose protein product may influence gene transcription in a global fashion. |
| Databáze: | OpenAIRE |
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