Apoptosis in fimbriae of fallopian tubes and endometrium in pyoinflammatory adnexal diseases

Autor:	A V, Zhdanov, D F, Kurbanova, M P, Davydova, L Yu, Sosulina, L S, Ezhova, G T, Sukhikh
Rok vydání:	2002
Předmět:	Adult Inflammation Tumor Necrosis Factor-alpha Apoptosis Receptors Tumor Necrosis Factor Endometrium Antigens CD Receptors Tumor Necrosis Factor Type I Adnexal Diseases In Situ Nick-End Labeling Humans Female fas Receptor Fallopian Tubes
Zdroj:	Bulletin of experimental biology and medicine. 135(2)
ISSN:	0007-4888
Popis:	In patients with pyoinflammatory adnexal diseases moderate or intense DNA degradation was observed in the majority of epithelial, stromal, and inflammatory infiltration cell in inflammatory foci in the fimbrial compartment of fallopian tubes without signs of tissue destruction. Expression of TNFR1 gene increased 2.7-fold and expression of Fas gene decreased 3.1-fold compared to intact endosalpinx, which indicates induction of apoptosis triggered by tumor necrosis factor-alpha and inhibition of the Fas-dependent pathway. No signs of apoptosis were detected in the endometrium. Generalized apoptosis in the fimbrial compartment of the tubes can be a mechanism limiting the inflammatory process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4f308b3525829e5fcfc7926260477aa8 https://pubmed.ncbi.nlm.nih.gov/12802421 Zobrazit plný text záznamu Full text from SpringerLink