[Acute kidney injury and severe malaria in adults: A monocentric descriptive study in Madagascar using KDIGO criteria]

Autor: Rova Malala Fandresena, Randrianarisoa, Eliane Mikkelsen, Ranivoharisoa, Mohamed, Ahmed, Benja, Ramilitiana, Nancy Lorena, Rakotomalala, Mamy Jean de Dieu, Randria, Willy Franck Harilalaina, Randriamarotia
Jazyk: francouzština
Rok vydání: 2020
Předmět:
Zdroj: Nephrologietherapeutique. 17(6)
ISSN: 1872-9177
Popis: Acute Kidney Injury (AKI) is one of the criteria for severe malaria with a varied incidence. Our objectives are to determine the prevalence of malaria-associated AKI and to report the characteristics of patients with the evolution of cases.This is a 5-year retrospective descriptive study from January 1, 2015 to December 31, 2019 in the Infectious Diseases department of the University Hospital Center of Befelatanana Antananarivo. Among 379 patients diagnosed, 103 patients (27,18%) with associated AKI were included. We used the criteria of Kidney Disease Improving Global Outcomes group to define AKI.The prevalence of AKI was 27.18%. The mean age of patients was 34.92 years and the sex-ratio was 3.68. Plasmodium falciparum was the causative agent in 98.06% of cases followed by Plasmodium vivax. Diuresis was preserved in 69.86% of cases. Jaundice was the main sign of severity associated (49.51%). The mean creatinine level was 466.93μmol/L. The evolution was favorable under antimalarial drug and rehydration. Dialysis was required in 25.24% of cases. Thirteen patients had died, a rate of 12.62%, of which 8 patients (61.54%) had dialysis criteria but had not been purged for economic reasons.AKI is a frequent complication of malaria. It is responsible for significant mortality despite improved care in the fight against malaria.
Databáze: OpenAIRE