Antigenic Drift of A/H3N2/Virus and Circulation of Influenza-Like Viruses During the 2014/2015 Influenza Season in Poland
| Autor: | Bednarska, K., Hallmann-Szelińska, E., Kondratiuk, K., Brydak, L. B. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Antigenic drift Adolescent Rhinovirus viruses Respiratory Syncytial Virus Infections Real-Time Polymerase Chain Reaction Article Adenovirus Infections Human Young Adult Influenza A Virus H1N1 Subtype Influenza Human Humans Epidemics Child Antigens Viral Aged Paramyxoviridae Infections Picornaviridae Infections Adenoviruses Human Influenza A Virus H3N2 Subtype Genetic Drift Infant Newborn virus diseases Infant Middle Aged Influenza Virus Coronavirus Influenza B virus Mismatch Influenza Vaccines Child Preschool Respiratory Syncytial Virus Human Paramyxovirinae Female Poland Seasons Infection Coronavirus Infections Vaccine Multiplex Polymerase Chain Reaction |
| Zdroj: | Respiratory Contagion |
| Popis: | Morbidity rates of influenza could be greatly reduced due to vaccination. However, the virus is able to evolve through genetic mutations, which is why vaccines with updated composition are necessary every season. Their effectiveness depends on whether there is a good antigenic match between circulating viruses and vaccine strains. In Poland, the 2014/2015 influenza epidemic started in week 5 (January/February) of 2015 and continued until week 17 (April) of 2015. The influenza activity was moderate with the highest incidence of influence-like illness at week 10/2015 (March). During that season, antigenic drift of influenza virus A/H3N2/ occurred causing higher rates of A/H3N2/ infections. Among the 2416 tested specimens, 22.6 % of influenza cases were positive for A/H3N2/, while A/H1N1/pdm09 constituted 14.6 % cases. Influenza A viruses were detected in co-circulation with influenza B viruses; the latter amounted to 34.1 % of all influenza detections. Other detected causes of influenza-like illness consisted of respiratory syncytial virus (RSV), being predominant, and, sporadically, human coronavirus, parainfluenza 1-3, rhinovirus, and adenovirus. Despite low vaccine effectiveness of solely one component, A/H3N2/, the vaccine could mitigate or shorten the length of influenza infection and reduce the number of severe outcomes and mortality. Thus, vaccination against influenza remains the most effective way to prevent illness and possibly fatal outcomes. |
| Databáze: | OpenAIRE |
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