| Autor: |
G, Petiti Martin, M, Castellanos González, J, Sanz Bueno, M, Burgués Calderón, M, Villar Buil, F, Vanaclocha, J L, Peralto |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Anales de pediatria (Barcelona, Spain : 2003). 77(4) |
| ISSN: |
1695-9531 |
| Popis: |
Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin. Generalised eruptive histiocytosis is a rare, benign, self-healing, non-Langerhans' cell histiocytosis (non-LCH). We report the case of an 8-year-old girl with sarcoidosis who was misdiagnosed as non-LCH. She was treated with oral corticosteroids, methotrexate and adalimumab, but there was insufficient control of ocular disease. The introduction of infliximab achieved a control of the uveitis and enabled the corticosteroid dose to be tapered. In some cases of sarcoidosis the lack of well-organised granuloma formation at the beginning of the disease, and the presence of prominent giant cells may suggest alternative diagnoses, such as non-LCH. Although the experience of tumour necrosis factor-α antagonists use in children with sarcoidosis is limited, these drugs may be helpful for those patients experiencing a severe and refractory disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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