Mutation screening of the dopamine D1 receptor gene in Tourette's syndrome and alcohol dependent patients

Autor:	M, Thompson, D E, Comings, L, Feder, S R, George, B F, O'Dowd
Rok vydání:	1998
Předmět:	Alcoholism Obsessive-Compulsive Disorder Attention Deficit Disorder with Hyperactivity Receptors Dopamine D1 DNA Mutational Analysis Humans Point Mutation Genetic Testing Polymorphism Single-Stranded Conformational Tourette Syndrome
Zdroj:	American journal of medical genetics. 81(3)
ISSN:	0148-7299
Popis:	We report a single stranded conformational polymorphism (SSCP) analysis of the coding region of the dopamine D1 receptor (DRD1) in Tourette's syndrome (n = 50) and control (n = 50) subjects. Tourette's syndrome populations with comorbidity for attention deficit-hyperactivity disorder (AD-HD) (n = 35) and obsessive compulsive disorder (OCD) (n = 30) were also screened. As a related study, we also screened patients diagnosed with alcohol dependence (n = 72). The present study discovered no DRD1 coding region mutations in any of the Tourette's syndrome or alcohol dependent patients. One silent mutation, a C for a T at Ile49, was discovered in one control subject. The non-polymorphic structure of the DRD1 gene among the Tourette's syndrome, Tourette's syndrome comorbid with AD-HD and OCD and the alcohol dependent populations screened by SSCP suggests that coding region mutations of the DRD1 gene are unlikely to contribute to the inheritance of these disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4ec7368d0db55b50a7337a15dfe09ca1 https://pubmed.ncbi.nlm.nih.gov/9603612 Zobrazit plný text záznamu Plný text