| Autor: |
Yolande I, Openda, Bokolombe P, Ngoy, Tebello, Nyokong |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Frontiers in Chemistry |
| ISSN: |
2296-2646 |
| Popis: |
New asymmetrical porphyrin derivatives containing a p-hydroxyphenyl moiety and p-acetylphenyl moieties along with their functionalized silver-detonation nanodiamonds nanohybrids were characterized and their photophysicochemical properties were established. The study provides evidence that the metalated porphyrin derivatives were red-shifted in absorption wavelength and possessed high singlet oxygen quantum yield comparative to the unmetalated core, thus making them suitable agents for photodynamic antimicrobial chemotherapy. As a result of conjugation to detonation nanodiamonds and silver nanoparticles, these compounds proved to be more effective as they exhibited stronger antibacterial and anti-biofilm activities on the multi-drug resistant S. aureus strain due to synergetic effect, compared to Ps alone. This suggests that the newly prepared nanohybrids could be used as a potential antimicrobial agent in the treatment of biofilms caused by S. aureus strain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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