| Autor: |
Sami, Viskin, Michael, Berger, Maya, Ish-Shalom, Nomi, Malov, Mira, Tamari, Michal, Golovner, Meyara, Kehati, David, Zeltser, Arie, Roth |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
The Israel Medical Association journal : IMAJ. 7(12) |
| ISSN: |
1565-1088 |
| Popis: |
Chlorpromazine is a dopamine-receptor antagonist antipsychotic agent. Because of its strong alpha-blocking and sedative actions, it has also been used as emergency therapy for extreme arterial hypertension. Published reports to date have included very small numbers of patients (i.e., 5-30).To analyze data on almost 500 patients who received intravenous chlorpromazine for the emergency treatment of uncontrolled symptomatic hypertension in the pre-hospital setting.We reviewed data from 496 consecutive patients who received intravenous chlorpromazine as emergency therapy for uncontrolled symptomatic hypertension. Chlorpromazine was injected intravenously. The dose was 1 mg every 2-5 minutes until the systolic pressure wasor =140 mmHg and the diastolic pressureor =100 mmHg with alleviation of symptoms.The mean dose of chlorpromazine administered was 4.5 +/- 5 mg (range 1-50 mg). Only 33 patients (7%) required10 mg. Chlorpromazine reduced systolic BP from 222.82 +/- 26.31 to 164.93 +/- 22.66 mmHg (P0.001) and diastolic BP from 113.5 +/-16.63 to 85.83 +/- 11.61 mmHg (P0.001). The sinus rate decreased from 97.9 +/- 23.5 to 92.2 +/- 19.7 beats per minute (P0.001). These results were achieved within the first 37 +/- 11 minutes.Intravenous chlorpromazine is safe and effective when used as emergency treatment for uncontrolled symptomatic hypertension. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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