Gain-of-function

Autor: Priscila, Villalvazo, Sol, Carriazo, Jorge, Rojas-Rivera, Adrián M, Ramos, Alberto, Ortiz, Maria Vanessa, Perez-Gomez
Rok vydání: 2022
Zdroj: Clinical kidney journal. 15(11)
ISSN: 2048-8505
Popis: Systemic lupus erythematosus (SLE) is a chronic and inflammatory autoimmune disease of unknown origin that may cause kidney disease, i.e. lupus nephritis (LN). Within a wider trend towards an expanding field of genetic causes of kidney disease, two recent reports have emphasized the role of Mendelian autoimmune disorders in causing LN both in children and in young adults. Loss-of-function (LOF) variants of tumor necrosis factor alpha-induced protein 3 (
Databáze: OpenAIRE