| Autor: |
G R, Solares, R G, Zamenhof |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Radiation research. 144(1) |
| ISSN: |
0033-7587 |
| Popis: |
A novel approach to the microdosimetry of neutron capture therapy has been developed using high-resolution quantitative autoradiography (HRQAR) and two-dimensional Monte Carlo simulation. This approach has been applied using actual cell morphology (nuclear and cytoplasmic cell structures) and the measured microdistribution of boron-10 in a transplanted murine brain tumor (GL261) containing p-boronophenylalanine (BPA) as the boron compound. The 2D Monte Carlo transport code for the alpha and 7Li charged particles from the 10B(n,alpha)7Li reactions has been developed as a surrogate to a full 3D approach to calculate a variety of different microdosimetric parameters. The HRQAR method and the surrogate 2D Monte Carlo approach are described in detail and examples of their use are presented. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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