T1 measurement using a short acquisition period for quantitative cardiac applications
| Autor: | David M, Higgins, John P, Ridgway, Aleksandra, Radjenovic, U Mohan, Sivananthan, Michael A, Smith |
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| Rok vydání: | 2005 |
| Předmět: |
Gadolinium DTPA
Models Statistical Time Factors Dose-Response Relationship Drug Phantoms Imaging Heart Ventricles Myocardium Contrast Media Reproducibility of Results Models Theoretical Image Enhancement Magnetic Resonance Imaging Perfusion Electrocardiography Coronary Circulation Image Processing Computer-Assisted Animals Humans Gels |
| Zdroj: | Medical physics. 32(6) |
| ISSN: | 0094-2405 |
| Popis: | Myocardial signal intensity curves for myocardial perfusion studies may be made quantitative by the use of T1 measurements made after the first-pass of contrast agent. A short data acquisition method for T1 mapping is presented in which all data for each T1 map are acquired in a short breath hold, and the slice geometry and timing in the cardiac cycle exactly match that of the dynamic first-pass perfusion sequence. This allows accurate image registration of the T1 map with the first-pass series of images. The T1 method is based on varying the preparation-pulse delay time of a saturation recovery sequence, and in this implementation employs an ECG-triggered, single-shot, spoiled gradient echo technique with SENSE reconstruction. The method allows T1 estimates of three slices to be made in fifteen heartbeats. For a range of samples with T1 values equivalent to those found in the myocardium during the first-pass of contrast agent, T1 estimates were accurate to within 6%, and the variation between slices was 2% or less. |
| Databáze: | OpenAIRE |
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