| Autor: |
O L, Voronova, O V, Neupokoeva, E P, Fedorova, A E, Prosenko, A A, Churin |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 73(10) |
| ISSN: |
0869-2092 |
| Popis: |
Beginning with the first hours of experiments, cisplatin evoked an increase of chromosomal aberrations in CBA/CaLac bone marrow cells. Significant increase of structural infringements of chromosomes due to chromatid breaks was revealed in metaphase plates of murine bone marrow preparations through 24 h after cisplatin intraperitoneal introduction. In late terms of research (90th day), the high level of aberrations of chromosomes was retained. The most pronounced correction of cisplatin mutagenicity was achieved using a preliminary course of thiophan introduction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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