Estrogen modulation of apolipoprotein(a) expression. Identification of a regulatory element
| Autor: | D, Boffelli, D A, Zajchowski, Z, Yang, R M, Lawn |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Transcriptional Activation
Base Sequence Estradiol DNA Mutational Analysis Molecular Sequence Data Estrogen Receptor alpha Estrogens Plasminogen Regulatory Sequences Nucleic Acid Transfection DNA-Binding Proteins Enhancer Elements Genetic Gene Expression Regulation Receptors Estrogen Genes Reporter Tumor Cells Cultured Humans Promoter Regions Genetic Apolipoproteins A Protein Binding |
| Zdroj: | The Journal of biological chemistry. 274(22) |
| ISSN: | 0021-9258 |
| Popis: | Elevated plasma levels of the lipoprotein particle Lp(a) are a major risk factor for cardiovascular disease. Lp(a) plasma levels are determined by the level of expression of its characteristic protein component, apo(a). Apo(a) expression is modulated by several hormones, of which estrogens are the best known. The chromosomal region responsible for estrogen response was identified within an apo(a) enhancer located at approximately 26 kilobases from the apo(a) promoter. Although the estrogen-responsive unit contains a potential estrogen response element, binding of estrogen receptor-alpha to DNA was not necessary. The receptor, activated by bound estradiol, interacts through its transactivation domains with a transcription factor necessary for the function of the enhancer, preventing its binding to DNA. |
| Databáze: | OpenAIRE |
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