| Autor: |
Shinghung, Mak, Zheng, Liu, Liangmiao, Wu, Baojian, Guo, Fangcheng, Luo, Ziyan, Liu, Shengquan, Hu, Jiajun, Wang, Guozhen, Cui, Yewei, Sun, Yuqiang, Wang, Gaoxiao, Zhang, Yifan, Han, Zaijun, Zhang |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
ACS chemical neuroscience. 11(3) |
| ISSN: |
1948-7193 |
| Popis: |
We have previously designed and synthesized a series of novel memantine nitrates, and some of them have shown neuroprotective effects; however, the detailed mechanisms remain unknown. In this study, we demonstrated that MN-12, one of the memantine nitrates, concentration-dependently protected against glutamate-induced neurotoxicity in rat primary cultured cerebellar granule neurons (CGNs). Western blotting assays revealed that MN-12 might possess neuroprotective effects through the inhibition of ERK pathway and activation of PI3K/Akt pathway concurrently. Moreover, MN-12 concentration-dependently dilated precontracted rat middle cerebral artery through activation of NO-cGMP pathway |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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