[Chronotherapy combining 5-fluorouracil, folinic acid and carboplatin as first line treatment in metastatic colorectal cancer. A phase 2 study]
| Autor: | C, Focan, F, Kreutz, L, Longrée, M P, Graas, D, Focan-Henrard, N, Moeneclaey, A, David, J F, Biquet, R, Materne, J, Weerts, M, Delforge |
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| Jazyk: | francouzština |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Aged 80 and over Chronobiology Phenomena Male Dose-Response Relationship Drug Rectal Neoplasms Leucovorin Middle Aged Survival Analysis Drug Administration Schedule Carboplatin Antineoplastic Combined Chemotherapy Protocols Colonic Neoplasms Humans Female Fluorouracil Neoplasm Metastasis Colorectal Neoplasms Infusions Intravenous Aged |
| Zdroj: | Pathologie-biologie. 53(5) |
| ISSN: | 0369-8114 |
| Popis: | Seventy-two patients suffering from a metastatic colorectal cancer received, as first line treatment, a combination chronotherapy with 5-FU and folinic acid (infused from 10 pm to 10 am with a peak at 4 am, respectively at doses of 700 and 300 mg/m2 per day) and carboplatin (infused at the dose of 40 mg/m2 per day from 10 am to 10 pm with a peak at 4 pm). The courses of four days were repeated every two weeks. A major tumoral response was observed in 60% cases (68% in those not previously treated with adjuvant chemotherapy). The median times to progression and overall survival established at 11 and 27 months. The clinical (grades 3-4 in maximum 5% cases) and hematological (grades 3-4 in maximum 10-29% cases) toxicities were quite limited. Our observations suggest the interest to incorporate carboplatin in the combined infusional treatment of colorectal cancer. |
| Databáze: | OpenAIRE |
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