| Autor: |
M S M, Chan, D J, Roebuck, M-P, Yuen, C-K, Li, Y-L, Chan |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
AJNR Am J Neuroradiol |
| ISSN: |
0195-6108 |
| Popis: |
BACKGROUND AND PURPOSE: Hemosiderin and white matter lesions are 2 of the most common neurologic complications found on MR imaging that may be related to cranial irradiation and intrathecal methotrexate (MTX) therapy in childhood acute lymphoblastic leukemia (ALL). We evaluated the brains of patients previously treated for ALL with cranial irradiation and intrathecal MTX with MR imaging and tested the hypothesis that these patients have more MR evidence of central nervous system (CNS) injury than control patients who are in complete remission following systemic chemotherapy without cranial irradiation. METHODS AND MATERIALS: ALL patients recruited from a pediatric cancer center data base were examined at 1.5T by using Tl-weighted, T2-weighted, gradient echo (GE), and fluid-attenuated inversion recovery sequences. Patients treated in childhood for solid extracranial neoplasms were used as controls. RESULTS: Lesions consistent with old hemorrhage were detected in 23 (55%) of the ALL patients and in none of the control patients (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
