| Autor: |
S, Giardina, A, Michelotti, G, Zavattini, S, Finzi, C, Ghisalberti, F, Marzatico |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Minerva ginecologica. 62(3) |
| ISSN: |
0026-4784 |
| Popis: |
During and after menopause the skin shows up clearly how the lack of estrogen affects tissues, and menopause can in fact be considered a "multisystemic" disorder of connective tissue. The low menopausal estrogen levels combined with age-related skin changes, accelerating skin aging. This affects both the epidermis and the dermis: fibroblasts not only become fewer, but they produce 30% less collagen, reflecting its metabolic decline. Estrogens act on collagen synthesis by directly stimulating fibroblasts. However, hormone replacement can prevent the postmenopausal loss of collagen--or eliminate it once it has started. The results of the Women's Health Initiative study drastically changed Italian gynecologists' prescribing habits. Natural products with estrogen-like activity are increasingly accepted, since they have good effects on collagen synthesis and/or inhibit collagenase activity, with a reassuring safety profile. This was confirmed by an in vitro study that assessed the tonic-trophic properties of two treatments on cultured skin fibroblasts. Cells were treated with resveratrol either alone or combined with NAC 10-100-1000 μM. There was a dose-related increase in the rate of cell proliferation and in inhibition of collagenase activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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