Thrombolytic treatment and complement activation
| Autor: | A, Agostoni, M, Gardinali, D, Frangi, M, Cugno, C, Cafaro, L, Conciato, C, Sponzilli, E, Salmoirago |
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| Rok vydání: | 1994 |
| Předmět: |
Anaphylatoxins
Myocardial Infarction Radioimmunoassay Complement C4a Blood Pressure Complement C5a Complement Membrane Attack Complex Complement System Proteins Immunoenzyme Techniques Leukocyte Count Complement C3a Humans Streptokinase Thrombolytic Therapy Infusions Intravenous Complement Activation Glycoproteins |
| Zdroj: | Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna. 9(3) |
| ISSN: | 0393-9340 |
| Popis: | Details of possible complement activation in acute myocardial infarction (AMI) and the in vivo effects of fibrinolytic agents on this activation are not yet known. We measured complement activation in 40 patients with AMI: 20 were treated with streptokinase, and 20 did not receive any fibrinolytic agent. Anaphylatoxin C4a, C3a and membrane attack complexes SC5b-9 increased about 10-fold (p0.0001) during streptokinase infusion. There were no increases in complement catabolic products in AMI patients not treated with streptokinase. Significant transient leukopenia (-29.5%, 7.0 SEM, p = 0.001) and a drop in systolic pressure (-29%, 3.4 SEM, p0.0001) occurred after 15 min of streptokinase infusion simultaneously with the peak of anaphylatoxins in plasma. |
| Databáze: | OpenAIRE |
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