| Autor: |
A, Chachuła, W, Kranc, J, Budna, A, Bryja, S, Ciesiólka, K, Wojtanowicz-Markiewicz, H, Piotrowska, D, Bukowska, M, Krajecki, P, Antosik, K P, Brüssow, M, Bruska, M, Nowicki, M, Zabel, B, Kempisty |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Journal of biological regulators and homeostatic agents. 30(3) |
| ISSN: |
0393-974X |
| Popis: |
The mammalian cumulus-oocyte complex (COCs) promotes oocyte growth and development during long stages of folliculogenesis and oogenesis. Before ovulation, the follicle is formed by a variety of fully differentiated cell populations; cumulus cells (CCs) that tightly surround the female gamete, granulosa cells (GCs) and theca cells (TCs) which build the internal and external mass of the follicular wall. It is well documented that CCs surrounding the oocyte are necessary for resumption of meiosis and full maturation of the gamete. However, the role of the granulosa cells in acquisition of MII stage and/or full fertilization ability is not yet entirely known. In this article, we present an overview of mammalian oocytes and their relationship to the surrounding cumulus and granulosa cells. We also describe the processes of GCs differentiation and developmental capacity. Finally, we describe several markers of mammalian GCs, which could be used for positive identification of isolated cells. The developmental capacity of oocytes and surrounding somatic cells a fingerprint of folliculogenesis and oogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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