Antifungal Saponins from the Maya Medicinal Plant Cestrum schlechtendahlii G. Don (Solanaceae)
| Autor: | Chieu Anh Kim, Ta, J Antonio, Guerrero-Analco, Elizabeth, Roberts, Rui, Liu, Christopher D, Mogg, Ammar, Saleem, Marco, Otárola-Rojas, Luis, Poveda, Pablo, Sanchez-Vindas, Victor, Cal, Federico, Caal, Rajagopal, Subramaniam, Myron L, Smith, John T, Arnason |
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| Rok vydání: | 2015 |
| Předmět: |
Antifungal Agents
Magnetic Resonance Spectroscopy Plants Medicinal Molecular Structure Plant Extracts Cestrum Fungi Microbial Sensitivity Tests Saccharomyces cerevisiae Saponins Plant Leaves Fusarium Candida albicans Cryptococcus neoformans Ethnicity Spirostans Humans Medicine Traditional Solanaceae Phytotherapy |
| Zdroj: | Phytotherapy research : PTR. 30(3) |
| ISSN: | 1099-1573 |
| Popis: | Bioassay-guided fractionation of the crude extract (80% EtOH) of the leaves of Cestrum schlechtendahlii, a plant used by Q'eqchi' Maya healers for treatment of athlete's foot, resulted in the isolation and identification of two spirostanol saponins (1 and 2). Structure elucidation by MS, 1D-NMR, and 2D-NMR spectroscopic methods identified them to be the known saponin (25R)-1β,2α-dihydroxy-5α-spirostan-3-β-yl-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranoside (1) and new saponin (25R)-1β,2α-dihydroxy-5α-spirostan-3-β-yl-O-β-D-galactopyranoside (2). While 2 showed little or no antifungal activity at the highest concentration tested, 1 inhibited growth of Saccharomyces cerevisiae (minimum inhibitory concentration (MIC) of 15-25 μM), Candida albicans, Cryptococcus neoformans, and Fusarium graminearum (MIC of 132-198 μM). |
| Databáze: | OpenAIRE |
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