Rabbit models of cardiac mechano-electric and mechano-mechanical coupling

Autor: T Alexander, Quinn, Peter, Kohl
Rok vydání: 2016
Předmět:
AF
atrial fibrillation
Vm
membrane potential
Na+
sodium
ECC
excitation-contraction coupling
MEC
mechano-electric coupling
Slow force response
GsMTx-4
Grammostola spatulata mechanotoxin-4
SFR
slow force response
H+
hydrogen
Mechanics
Sinoatrial node
Article
KATP
stretch-sensitive ATP-inactivated potassium channel
L-type
long-lasting [calcium channel]
FSL
Frank-Starling mechanism
Animals
Humans
SACNS
cation non-selective stretch-activated channel
SAN
sinoatrial node
Mechanical Phenomena
Clswell
swelling-activated chloride channel
Models
Cardiovascular
Heart
Ca2+
calcium
SR
sarcoplasmic reticulum
MMC
mechano-mechanical coupling
BR
beating rate
Biomechanical Phenomena
Electrophysiological Phenomena
Electrophysiology
Atrium
K+
potassium
cardiovascular system
Ventricle
Rabbits
AP
action potential
VF
ventricular fibrillation
PVE
premature ventricular excitation
Zdroj: Progress in Biophysics and Molecular Biology
ISSN: 1873-1732
Popis: Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics in the heart. Whereas mechanical activity is usually seen as ‘the endpoint’ of cardiac auto-regulation, it is important to appreciate that the heart would not function without feed-back from the mechanical environment to cardiac electrical (mechano-electric coupling, MEC) and mechanical (mechano-mechanical coupling, MMC) activity. MEC and MMC contribute to beat-by-beat adaption of cardiac output to physiological demand, and they are involved in various pathological settings, potentially aggravating cardiac dysfunction. Experimental and computational studies using rabbit as a model species have been integral to the development of our current understanding of MEC and MMC. In this paper we review this work, focusing on physiological and pathological implications for cardiac function.
Databáze: OpenAIRE
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