| Autor: |
C L, Costa E Silva, M A T, Bortolini, N C, Batista, R S P, Silva, J B, Teixeira, É, Oliveira, R P, Souto, R A, Castro |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Climacteric : the journal of the International Menopause Society. 25(4) |
| ISSN: |
1473-0804 |
| Popis: |
This study aimed to verify the presence of polymorphism rs2165241 of the lysyl oxidase-like 1 (The study was previously approved by the local research and ethics board. Postmenopausal women were included and divided into POP (stages III and IV) and control (stages 0 and I) groups. Peripheral blood samples were collected, and the DNA sequence of interest was analyzed by real-time reverse-transcriptase polymerase chain reaction. We used logistic regression and considered a recessive model of inheritance for the analysis, withA total of 836 women were assessed: 426 POP cases and 410 controls. The frequencies of CC, CT and TT genotypes were similar in both groups. Age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.07; 1.14), number of vaginal births (OR = 17.06, 95% CI = 5.94; 48.97), family history (OR = 2.87, 95% CI = 1.57; 5.22) and weight of largest newborn (OR = 1.001, 95% CI = 1.0003; 1.001) were independent risk factors for POP, while multiple cesarean sections (two or more) was protective (OR = 0.17, 95% CI = 0.07; 0.42).No association was detected between rs2165241 of the |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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