Understanding binding affinity and specificity of modular protein domains: A focus in ligand design for the polyproline-binding families

Autor:	Jose C, Martinez, Francisco, Castillo, Javier, Ruiz-Sanz, Javier, Murciano-Calles, Ana, Camara-Artigas, Irene, Luque
Rok vydání:	2022
Předmět:	Binding Sites Proline Protein Domains Humans Ligands Peptides Protein Binding
Zdroj:	Advances in protein chemistry and structural biology. 130
ISSN:	1876-1631
Popis:	Within the modular protein domains there are five families that recognize proline-rich sequences: SH3, WW, EVH1, GYF and UEV domains. This chapter reviews the main strategies developed for the design of ligands for these families, including peptides, peptidomimetics and drugs. We also describe some studies aimed to understand the molecular reasons responsible for the intrinsic affinity and specificity of these domains.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4d2fb6c89f2e139eafdf9b29f1064ef1 https://pubmed.ncbi.nlm.nih.gov/35534107 Zobrazit plný text záznamu