PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms

Autor:	C J, Hauser, Z, Fekete, J M, Adams, M, Garced, D H, Livingston, E A, Deitch
Rok vydání:	2001
Předmět:	Ion Transport Neutrophils Humans Calcium Platelet Activating Factor Cells Cultured Signal Transduction
Zdroj:	Journal of leukocyte biology. 69(1)
ISSN:	0741-5400
Popis:	Many inflammatory mediators activate neutrophils (PMN) partly by increasing cytosolic calcium concentration ([Ca2+]i). Modulation of PMN [Ca2+]i might therefore be useful in regulating inflammation after shock or sepsis. The hemodynamic effects of traditional Ca2+ channel blockade, however, could endanger unstable patients. Store-operated calcium influx (SOCI) is known now to contribute to Ca2+ flux in "nonexcitable" cells. Therefore, we studied the role of SOCI in human PMN responses to the proinflammatory ligand PAF. PMN [Ca2+]i was studied by spectrofluorometry with and without external calcium. We studied the effects o
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4d11b51453a15af0b67cf9419a1f293d https://pubmed.ncbi.nlm.nih.gov/11200069 Zobrazit plný text záznamu Plný text