Heart rate variability and ischaemia in patients with coronary heart disease and stable angina pectoris; influence of drug therapy and prognostic value. TIBBS Investigators Group. Total Ischemic Burden Bisoprolol Study
| Autor: | F, Weber, H, Schneider, T, von Arnim, W, Urbaszek |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Nifedipine Adrenergic beta-Antagonists Myocardial Ischemia Reproducibility of Results Coronary Disease Middle Aged Calcium Channel Blockers Prognosis Angina Pectoris Circadian Rhythm Europe Double-Blind Method Heart Rate Electrocardiography Ambulatory Bisoprolol Humans Drug Therapy Combination Female Aged Follow-Up Studies Retrospective Studies |
| Zdroj: | European heart journal. 20(1) |
| ISSN: | 0195-668X |
| Popis: | Determination of the influence of therapy with bisoprolol and nifedipine on the heart rate variability of patients from the Total Ischemic Burden Bisoprolol Study and examination of the prognostic value.Four hundred and twenty-two patients with stable angina were included. The heart rate variability was determined over a period of 24 h. Parameters determined: standard deviation of the mean of all corrected RR intervals, standard deviation of all 5 min mean cycle lengths, square root of the mean of the squared differences of successive corrected RR intervals. Nifedipine reduced the mean values of all heart rate variability parameters tested. Square root of the mean of the square differences of successive corrected RR intervals increased under bisoprolol. Standard deviation of the mean of all corrected RR intervals and standard deviation of all 5 min mean cycle lengths increased from low baseline values and declined from higher baseline values. The increase in heart rate variability under therapy was accompanied by a tendency towards a better prognosis. Patients with an increase in heart rate variability and simultaneous complete suppression of ischaemia under therapy displayed no serious events in the course of one year.The increase in the heart rate variability, which can be regarded as prognostically favourable, was predominantly observed under bisoprolol. The parameter constellation of an increase in heart rate variability and complete ischaemia suppression on the 48-h Holter ECG was associated with the greatest benefit. |
| Databáze: | OpenAIRE |
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