| Autor: |
Miao-Deng, Liu, Deng-Ke, Guo, Run-Yao, Zeng, Wen-Hui, Guo, Xing-Lan, Ding, Chu-Xin, Li, Ying, Chen, Yunxia, Sun, Xian-Zheng, Zhang |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Small methods. 5(7) |
| ISSN: |
2366-9608 |
| Popis: |
Advances in enzymes involve an efficient biocatalytic process, which has demonstrated great potential in biomedical applications. However, designing a functional carrier for enzymes equipped with satisfactory degradability and loading efficiency, remains a challenge. Here, based on transformable liquid metal (LM), a spinose nanodrum is designed as protein carrier to deliver enzyme for tumor treatment. With the assistance of spines and a special drum-like shape, it is found that the spiny LM can carry much more enzymes than spherical LM under the same condition. Benefiting from the satisfactory enzyme loading efficiency of spiny LM, a plasma amine oxidase immobilized spinose LM nanosystem enveloped with epigallocatechin gallate (EGCG)-Fe |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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