Failure of ascrobic acid to inhibit the metabolic N-oxidation of the bladder carcingen 4-biphenylamine

Autor:	E, Brill, J L, Radomski
Rok vydání:	1977
Předmět:	Male Chromatography Gas Dogs Depression Chemical Urinary Bladder Carcinogens Aminobiphenyl Compounds Animals Female Ascorbic Acid In Vitro Techniques Oxidation-Reduction Nitroso Compounds
Zdroj:	Research communications in chemical pathology and pharmacology. 16(1)
ISSN:	0034-5164
Popis:	The effect of L-ascorbic acid on the in vivo metabolic N-oxidation of the bladder carcinogen 4-biphenylamine has been investigated in the dog. Gas chromatographic analysis of the urines of dogs receiving concomitant oral doses of L-ascorbic acid and 4-biphyenylamine showed no significant difference in the N-oxidized metabolites when compared to dogs receiving arylamine alone. The results indicate that pretreatment with large doses of L-ascorbic acid has no effect on the metabolic N-oxidation of 4-biphenylamine or on the urinary concentration of these metabolites. The failure of L-ascrobic acid to lower the urinary concentration of these presumed proximate urinary carcinogens casts doubt on its efficacy in bladder tumor prophylaxis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4cd909ef93a31b1ee865c190b2c29aae https://pubmed.ncbi.nlm.nih.gov/841184 Zobrazit plný text záznamu