| Autor: |
F, Valafar, S M, Ramirez-Busby, J, Torres, Lynthia V, Paul, T C, Rodwell, T C, Victor, C, Rodrigues, M T, Gler, V, Crudu, T, Catanzaro |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
International journal of mycobacteriology. 4(Suppl 1) |
| ISSN: |
2212-554X |
| Popis: |
By using whole genome sequencing (WGS), researchers are beginning to understand the genetic diversity of151 (130 INHPacDAP variant analysis revealed 22 novel catalase-peroxidase (Eleven of the 14 SNPs are resistance conferring, and it is believed that the remaining 8 combinatorial mutations are either compensatory in nature or, in combination with known SNPs, could increase resistance levels. Positive selection results indicate a diversifying evolutionary path to resistance more in line with long tail statistics and therefore indicate a departure from the traditional point mutation (or "hotspot") model that current molecular diagnostics are based on. Positive selection pressures indicate a future with elevated diagnostic and prognostic significance of the "long tail" (i.e., alternative mechanisms of resistance) and potentially diminishing significance of the canonical mutations (especially in South Africa and the Philippines), which could have significant future implications on narrowly targeting molecular diagnostics. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
