Dihydroactinidiolide, a natural product against Aβ
| Autor: | Mamali, Das, Sengodu, Prakash, Chirasmita, Nayak, Nandhini, Thangavel, Sanjeev Kumar, Singh, Paramasivam, Manisankar, Kasi Pandima, Devi |
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| Rok vydání: | 2018 |
| Předmět: |
Amyloid beta-Peptides
Free Radical Scavengers Molecular Dynamics Simulation Hemolysis Peptide Fragments Molecular Docking Simulation Mice Neuroprotective Agents Catalytic Domain Cell Line Tumor Acetylcholinesterase Animals Humans Cholinesterase Inhibitors Protein Multimerization Reactive Oxygen Species Benzofurans |
| Zdroj: | Bioorganic chemistry. 81 |
| ISSN: | 1090-2120 |
| Popis: | Synthesis of natural products has speeded up drug discovery process by minimizing the time for their purification from natural source. Several diseases like Alzheimer's disease (AD) demand exploring multi targeted drug candidates, and for the first time we report the multi AD target inhibitory potential of synthesized dihydroactinidiolide (DA). Though the activity of DA in several solvent extracts have been proved to possess free radical scavenging, anti bacterial and anti cancer activities, its neuroprotective efficacy has not been evidenced yet. Hence DA was successfully synthesized from β-ionone using facile two-step oxidation method. It showed potent acetylcholinesterase (AChE) inhibition with half maximal inhibitory concentration (IC |
| Databáze: | OpenAIRE |
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