| Autor: |
Toshiyuki, Miyashita, Tadahilo, Oshida |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Nihon rinsho. Japanese journal of clinical medicine. 66(1) |
| ISSN: |
0047-1852 |
| Popis: |
The ability of glucocorticoids (GCs) to kill lymphoid cells via a process called apoptosis has led to their inclusion in essentially all chemotherapy protocols for lymphoid malignancies. Since GC receptor(GR) is a ligand-dependent transcription factor, there should be genes mediating apoptosis among the ones whose expression is induced by GC. This review summarizes recent advances related to the molecular basis of GC-induced apoptosis, focusing on microarray analysis. Various groups of genes have been identified as candidate target genes of GR including the ones encoding Bcl-2 family proteins and calcineurin inhibitors. Although further investigation is required to determine the genes causally involved in GC-induced apoptosis, the studies described here will hopefully lead to more efficient treatments of lymphoid malignancies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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