| Autor: |
Katsuyuki, Doi, Takanori, Asano, Takashi, Kinoshita |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Nihon Jibiinkoka Gakkai kaiho. 113(6) |
| ISSN: |
0030-6622 |
| Popis: |
Therapy-related myelodysplastic syndrome (t-MDS) and therapy-related leukemia (TRL) are reported increasingly often, and we report two cases of T-MDS after concurrent chemoradiotherapy (CCRT) with oral cancer. Patients underwent CCRT with cisplatin (CDDP) or carboplatin (CBDCA). The interval between primary CCRT and t-MDS was 11 months in 1 case and 14 years in the other. Chromosomal analysis indicated abnormal karyotypes. Platinum has a relatively lower t-MDS risk than alkylating agents or topoisomerase II inhibitors, but our experience supports concurrent use of radiotherapy with platinum affects the risk of t-MDS. If pancytopenia is detected after CCRT, bone marrow and cytogenetic examinations should be conducted to rule out T-MDS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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