Influence of caffeine on the induction of SOS functions recA and umuC by mitomycin C in Escherichia coli

Autor:	J, Kim, R E, Levin
Rok vydání:	1990
Předmět:	Alkylating Agents Caffeine Mitomycin Escherichia coli Gene Expression Regulation Bacterial SOS Response Genetics Mitomycins
Zdroj:	Microbios. 64(260-261)
ISSN:	0026-2633
Popis:	Caffeine alone induced the SOS functions recA and umuC in wild type recA-lacZ and umuC-lacZ fusion systems in Escherichia coli strains. Caffeine was also able to induce umuC in a umuC-lacZ fusion strain defective in excision repair. Caffeine however was unable to significantly induce recA in a recA-lacZ fusion strain defective in excision repair. Mitomycin C (MMC) at a concentration of 0.5 microgram/ml functioned as a stronger inducer of recA and umuC than caffeine at 2 mg/ml. Cell growth in the presence of both caffeine (2 mg/ml) and MMC (0.05, 0.1 and 0.5 microgram/ml) resulted in primarily an additive induction of recA and umuC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4c7d506f8cff36a9f1250210455b6b78 https://pubmed.ncbi.nlm.nih.gov/2128110 Zobrazit plný text záznamu