| Autor: |
Ting, Dong, Yaxian, Jiang, Zhengfa, Li, Hongmei, Ouyang, Qin, Zhang |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 33(5) |
| ISSN: |
1007-8738 |
| Popis: |
Objective To investigate the immunophenotypic characteristics of acute promyelocytic leukemia (APL) and its clinical significance. Methods Immunophenotyping was performed by four-color flow cytometry with CD45/SSC-lin gating for neoplastic cells and was divided into five levels according to the intensity of antigen expression. Results The expression intensity and percentage of typical APL phenotypes were: myeloperoxidase (MPO) and CD33 were consistently expressed (100%); CD38 (82.35%), CD13 (64.71%), CD64 (50%), CD123 (47.06%) and CD117 (44.12%) were partially expressed. HLA-DR (97.06%) and CD34 (99.02%) were negative. Post-chemotherapy remission rate in the Lym+APL patients was significantly lower than that in the Lym-APL patients. Conclusion The typical phenotypic characteristics in APL immunophenotyping were high SSC, CD33 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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