Regulation of insulin-like growth factors and IGF-binding proteins in bone tumours

Autor:	W, Zumkeller, O, Groth, J, Commentz
Rok vydání:	1996
Předmět:	Insulin-Like Growth Factor Binding Proteins Osteosarcoma Bone Development Insulin-Like Growth Factor II Endopeptidases Tumor Cells Cultured Animals Humans Bone Neoplasms Insulin-Like Growth Factor I Cell Division Signal Transduction
Zdroj:	Growth regulation. 6(1)
ISSN:	0956-523X
Popis:	Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) are important regulators of growth and development in normal bone and bone tumours. IGFs contribute to about 50% of basal bone cell proliferation. Their mitogenic actions is either enhanced or inhibited by specific IGFBPs which are also regulated by a variety of factors. This system is further complicated by the presence of specific proteases for IGFBPs. Serine proteases are secreted by malignant bone tumours and the hydrolysis of IGFBPs increases the bioavailability of IGFs. In addition, the autocrine production of IGFs may facilitate the development of bone tumours and metastatic lesions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4c66d96714b57f847b8be78618441302 https://pubmed.ncbi.nlm.nih.gov/8717445 Zobrazit plný text záznamu