| Autor: |
Winston, Corona, Deepa J, Karkera, Robert H, Patterson, Nirmal, Saini, Gregory D, Trachiotis, Louis Y, Korman, Benita, Liu, Edmund P, Alexander, Arturo S, De la Pena, Alvin B, Marcelo, Robert, Wadleigh |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Anticancer research. 24(3a) |
| ISSN: |
0250-7005 |
| Popis: |
The aim of this study was to investigate whether a candidate gene, Sciellin (SCEL), mapping to the chromosome 13q21-q31 is mutated in esophageal cancer.The coding region and intron-exon junctions of SCEL were sequenced in 13 esophageal squamous cell cancers and matching normal esophageal samples to detect mutations.Three single nucleotide polymorphisms were detected in SCEL of which two were silent mutations (L640L and H654H) and one missense mutation (R366K).Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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