| Autor: |
O, Denga, T, Pyndus, V, Gargin, S, Schneider |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Georgian medical news. (273) |
| ISSN: |
1512-0112 |
| Popis: |
Metabolic syndrome (MS) can be characterized as the clustering of combination of impaired glucose regulation, metabolic disorders accompanied by abdominal obesity, hyperglycemia, high blood pressure and dyslipidemia. Detection of changes in microcirculatory bed (MCB) of oral cavity in metabolic syndrome could be important for completion of gap for developing of adequate therapeutical measure for prevention of pathological periodontal disorder that was the purpose of our study. We performed experimental investigation with modulation of MS (on white male rats 1.5-2 months of age) during 70 days using a diet in which the oral pork fat was daily administered orally (40% of the rat weight), and 10% fructose ad libitum solution was used also instead of drinking water. Obtained specimens of soft tissues of the oral cavity were stained with histological and histochemical methods. The microscopic study with statistical analysis was performed. As result of our work it is established that metabolic syndrome is realized in significant changes in the microcirculatory bed of the periodontal, which can underlie the pathogenesis of inflammatory changes. Microcirculation disorders are characterized by significant changes in microangioarchitecture with uneven congestion, reduced specific volume of MCB vessels, thickening of vascular walls. Specific density of MCB vessels is changed from 27.40±8.31 % to 13.16±1.94 % statistically. Growth of connective tissue is developed as result of hypoxia with presence of collagen fibers in all layers of oral mucosa lamina propria. Specific density of rough connective tissue is increased from 21.47±6.38 % to 39.87±5.39 %. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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