Evaluation of an antigen assay for diagnosing acute and chronic hepatitis E genotype 4 infection

Autor: Haiying, Zhang, Huiying, Rao, Yijin, Wang, Jianghua, Wang, Xiangsha, Kong, Ying, Ji, Ling, Zhu, Yan, Liu, Jilian, Fang, Ming, Yang, Bifen, Luo, Zhenyu, Wang, Yijun, Shi, Yu, Wang, Hao, Wang, Jingmin, Zhao, Lai, Wei
Rok vydání: 2018
Předmět:
Zdroj: Journal of gastroenterology and hepatology. 34(2)
ISSN: 1440-1746
Popis: Results obtained from different hepatitis E virus (HEV) tests are usually inconsistent. The detection of serum HEV antigen (Ag) has been suggested to be more sensitive for the diagnosis of genotypes 1 and 3 HEV.We compared the diagnostic accuracies of serum HEV Ag and HEV RNA by using 202 serum samples from patients suspected acute viral hepatitis.The HEV Ag assay was 100% specific. The lower detected levels of viremia ranged from 10The presence of HEV Ag has good consistency with HEV RNA in both acute and chronic genotype 4 hepatitis E. HEV Ag is a more promising serum marker to identify active genotype 4 HEV infection than anti-HEV IgM and HEV RNA.
Databáze: OpenAIRE