Combination therapy for Alzheimer's disease and related dementias

Autor:	Martin M, Bednar
Rok vydání:	2019
Předmět:	Alzheimer Disease Animals Humans Dementia Combined Modality Therapy
Zdroj:	Progress in molecular biology and translational science. 168
ISSN:	1878-0814
Popis:	The failure to date of all disease modifying therapies for Alzheimer's disease and related dementias requires a serious rethinking of the field's approach to therapeutic interventions. This begins with the acknowledgement that the great majority of sporadic neurodegenerative dementias are the result of more than one toxic protein/species. While there are challenges to the initiation of clinical trials targeting more than one mechanism, there is an urgent need for a paradigm shift where a pleotropic and personalized approach is implemented to address the devastating personal and societal consequences of neurodegenerative dementias.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4bb7de7b1274ebbce65e01e3ab3b9229 https://pubmed.ncbi.nlm.nih.gov/31699322 Zobrazit plný text záznamu