X Marks the Spot: Mapping Similarity Between Clinical Trial Cohorts and US Counties
| Autor: | Matthew C, Lenert, Dara E, Mize, Colin G, Walsh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Patient Selection
Datasets as Topic Hispanic or Latino Articles United States Black or African American Diabetes Mellitus Type 2 Research Design Hypertension Pragmatic Clinical Trials as Topic Health Status Indicators Humans Multicenter Studies as Topic human activities Randomized Controlled Trials as Topic |
| Zdroj: | AMIA ... Annual Symposium proceedings. AMIA Symposium. 2017 |
| ISSN: | 1942-597X |
| Popis: | When patients and doctors collaborate to make healthcare decisions, they rely on clinical trial results to guide discussions. Trials are designed to recruit diverse participants. The question remains — how well do trial results apply to me or to people who live in our area? This study compared one complete clinical trial dataset (SPRINT) and one published study (ACCORD) to the Community Health Status Indicators dataset to assess the similarity of the trial populations to US county populations. Counties up to 495 miles to the closest SPRINT trial site and up to 712 miles to the closest ACCORD trial site had populations that were significantly more similar to the study cohort than counties farther away. The investigators detail a generalizable method for both assessing recruitment gaps in large multicenter trials and creating maps for clinicians to provide intuition on trial applicability in their area. |
| Databáze: | OpenAIRE |
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