Mycophenolate mofetil (RS-61443): preclinical, clinical, and three-year experience in heart transplantation
| Autor: | D O, Taylor, R D, Ensley, S L, Olsen, D, Dunn, D G, Renlund |
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| Rok vydání: | 1994 |
| Předmět: |
Graft Rejection
Male Time Factors In Vitro Techniques Middle Aged Mycophenolic Acid Kidney Transplantation Animals Heart Transplantation Humans Multicenter Studies as Topic Drug Therapy Combination Female Controlled Clinical Trials as Topic Immunosuppressive Agents Randomized Controlled Trials as Topic |
| Zdroj: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 13(4) |
| ISSN: | 1053-2498 |
| Popis: | Mycophenolate mofetil (formerly known as RS-61443) is a morpholinoethyl ester of mycophenolic acid. Mycophenolic acid is a unique immunosuppressive agent because of its mechanism of action. By inhibiting the de novo pathway of purine synthesis, mycophenolic acid suppresses lymphocyte function much more than that of neutrophil, erythrocyte, and other rapidly dividing cell lines which can use the salvage purine synthesis pathway. Mycophenolate mofetil has been shown to be an effective immunosuppressive agent in both animal models and early human trials. This article describes the history, biochemistry, pharmacology, in vitro and in vivo effects, and clinical trials of myophenolate mofetil. In addition, previously unpublished 3-year follow-up of heart transplant recipients receiving mycophenolate mofetil is reported. |
| Databáze: | OpenAIRE |
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