TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function

Autor:	Alastair J M, Watson, Kevin R, Hughes
Rok vydání:	2012
Předmět:	Mice Tumor Necrosis Factor-alpha Animals Humans Apoptosis Intestinal Mucosa Inflammatory Bowel Diseases Tight Junctions
Zdroj:	Annals of the New York Academy of Sciences. 1258
ISSN:	1749-6632
Popis:	Although epithelial cells are continuously shed from the surface of the intestine, the intestinal epithelium maintains the integrity of the epithelial barrier. This is achieved through a highly dynamic process involving reorganization of tight junction and adherens junction proteins. This process both ejects the cell from the epithelial monolayer and plugs the gap left after the cell is shed. Inflammatory insults can trigger a disturbance of these barrier functions by increasing rates of cell shedding. Epithelial cell shedding and loss of barrier can be visualized by confocal laser endomicroscopy in humans. A simple grading system of confocal laser endomicroscopic images can stratify inflammatory bowel disease (IBD) patients in remission into those who will relapse over the subsequent six months and those who will not. Here, we review the mechanisms governing maintenance of these barrier functions and the implications of inflammation-induced barrier dysfunction in IBD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4b9a1eef8947573bbae3e6eb9ffc1af9 https://pubmed.ncbi.nlm.nih.gov/22731709 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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