| Autor: |
M, Rivero Fernández, J M, Riesco, V F, Moreira, A, Moreno, A, López San Román, G, Arranz, L, Ruiz Del Arbol |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 100(11) |
| ISSN: |
1130-0108 |
| Popis: |
Adverse drug reactions (hepatotoxicity) are a frequent cause of acute liver injury with a wide clinical and histological spectrum. An early recognition of drug-related liver disease has been considered essential in clinical practice due to potential risks. In most cases exposure discontinuation improves the clinical picture.Steroids are used in a variety of clinical settings. However, intravenous steroids have rarely been associated with hepatotoxicity. We report the case of a middle-aged woman with multiple sclerosis who received a bolus of methylprednisolone on three occasions for the management of relapsing disease, with the development of repeated episodes of elevated liver enzymes after corticoid administration. In the third episode a liver biopsy was performed, which showed acute hepatitis with bridging necrosis; such histological picture has not been described before in patients treated with intravenous steroids. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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