| Autor: |
Priyadarshini, Sakthi Mohan, Faridah, Sonsuddin, Azizah Binti, Mainal, Rosiyah, Yahya, Gopinath, Venkatraman, Jamuna, Vadivelu, Dunia A, Al-Farraj, Amal M, Al-Mohaimeed, Khaloud Mohammed, Alarijani |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Antibiotics |
| ISSN: |
2079-6382 |
| Popis: |
This paper presents for the first time a successful fabrication of ternary ZnO/TiO2/Ag nanocomposites consisting of zinc oxide (ZnO), titania (TiO2) and silver (Ag) nanoparticles (NPs) synthesised using Morinda citrifolia fruit (MCF) extract. ZnONPs were synthesised using the co-precipitation method, and TiO2 and Ag were introduced into the precursor solutions under microwave irradiation to obtain ZnO/TiO2/Ag nanocomposites (NCs). This material demonstrated enhanced bactericidal effect towards bacterial pathogens compared to that of the binary TiO2/Ag, Ag and TiO2 alone. In vitro cytotoxicity results of the as-synthesised ZnO/TiO2/AgNCs on RAW 264.7 macrophages and A549 cell lines revealed a negative role in cytotoxicity, but contributed astoundingly towards antimicrobials as compared of Ag alone and binary Ag/TiO2. This study shows that the resultant ternary metal/bi-semiconductor nanocomposites may provide a therapeutic strategy for the eradication of bacterial pathogens without affecting the healthy mammalian cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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