Design, Synthesis, and Biological Evaluation of New Peripheral 5HT

Autor:	Minhee, Kim, Inseon, Hwang, Haushabhau S, Pagire, Suvarna H, Pagire, Wonsuk, Choi, Won Gun, Choi, Jihyeon, Yoon, Won Mi, Lee, Jin Sook, Song, Eun Kyung, Yoo, Seung Mi, Lee, Mi-Jin, Kim, Myung Ae, Bae, Dooseop, Kim, Heejong, Lee, Eun-Young, Lee, Jae-Han, Jeon, In-Kyu, Lee, Hail, Kim, Jin Hee, Ahn
Rok vydání:	2020
Předmět:	Male Mice Inbred ICR Drug Evaluation Preclinical Diet High-Fat Mice Inbred C57BL Rats Sprague-Dawley Mice HEK293 Cells Non-alcoholic Fatty Liver Disease Drug Design Microsomes Liver Serotonin 5-HT2 Receptor Antagonists Animals Humans
Zdroj:	Journal of medicinal chemistry. 63(8)
ISSN:	1520-4804
Popis:	Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including nonalcoholic steatohepatitis. Recent findings suggest that peripheral serotonin (5-hydroxytryptamine, 5HT) regulates energy homeostasis, including hepatic lipid metabolism. More specifically, liver-specific 5HT
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4b650224aa33f4bc18de7a818466f756 https://pubmed.ncbi.nlm.nih.gov/32285676 Zobrazit plný text záznamu