| Autor: |
R J, Baer, R J, Currier, M E, Norton, M C, Flessel, S, Goldman, D, Towner, L L, Jelliffe-Pawlowski |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Prenatal diagnosis. 35(12) |
| ISSN: |
1097-0223 |
| Popis: |
To describe adverse outcomes and fetal abnormalities in women with a positive prenatal screening result for more than one disorder.Study participants were drawn from a population of 452 901 women pregnant with singletons entering the California Prenatal Screening Program in their first-trimester. Risk assessment was provided for trisomy 21 and trisomy 18 in the first-trimester and trisomy 21, trisomy 18, neural tube defects, and Smith-Lemli-Opitz syndrome in the second-trimester. Inclusion in this study required positive screening for more than one of the screened conditions and a completed outcome of pregnancy survey.A total of 874 women met our study inclusion criteria. Over 25% of these pregnancies had a fetus with a chromosomal abnormality. Of the euploid pregnancies, 6.9% had a fetus with a major birth defect. Of the pregnancies with a fetus with neither a chromosomal abnormality nor a major birth defect, 9.3% ended in fetal demise. Overall, more than 50% of women with multiple positive screening results had either a fetus with a birth defect or a poor pregnancy outcome.Although it is rare to screen positive for more than one condition, such results indicate a very high risk for chromosomal abnormality, fetal demise, or structural abnormality. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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