Activity of

Autor: Felice, Valzano, Selene Rebecca, Boncompagni, Maria, Micieli, Tiziana, Di Maggio, Vincenzo, Di Pilato, Lorenzo, Colombini, Francesco, Santoro, Gianni, Pozzi, Gian Maria, Rossolini, Lucia, Pallecchi
Rok vydání: 2022
Předmět:
Zdroj: Microbiology spectrum. 10(4)
ISSN: 2165-0497
Popis: Chronic colonization by Pseudomonas aeruginosa is critical in cystic fibrosis (CF) and other chronic lung diseases, contributing to disease progression. Biofilm growth and a propensity to evolve multidrug resistance phenotypes drastically limit the available therapeutic options. In this perspective, there has been growing interest in evaluating combination therapies, especially for drugs that can be administered by nebulization, which allows high drug concentrations to be reached at the site of infections while limiting systemic toxicity. Here, we investigated the potential antibiofilm activity of
Databáze: OpenAIRE