Running on time: the role of circadian clocks in the musculoskeletal system
| Autor: | Michal, Dudek, Qing-Jun, Meng |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
circadian rhythm
Gilz glucocorticoid-induced leucine zipper RORE ROR/REV-ERB-binding element Mrf4 muscle-specific regulatory factor 4 muscle Grem2 gremlin 2 Noc nocturnin HBM high bone mass Dwarfism homoeostasis Fbxo32 F-box protein 32 LD light–dark MSC mesenchymal stem cell Review Article Tendons Mice TGF-β transforming growth factor-β Animals Humans Ihh Indian hedgehog Creb/CREB cAMP-responsive-element-binding protein PTH parathyroid hormone Muscle Skeletal Pgc1 Pparg co-activator 1 cartilage entrainment ADAM a disintegrin and metalloproteinase Bmal1 brain and muscle ARNT-like 1 KO knockout BMSC bone marrow-derived stem cell Arthritis Nr1d1 nuclear receptor subfamily 1 group D member 1 Calcinosis BMP bone morphogenetic protein Per period circadian clock CCG clock-controlled gene WT wild-type SCN suprachiasmatic nuclei ECM extracellular matrix Adrb2 β2-adrenergic receptor Cartilage MyoD myogenic differentiation Pparg peroxisome-proliferator-activated receptor γ Myf myogenic factor Cry cryptochrome circadian clock Sirt1 sirtuin 1 Locomotion Mmp matrix metalloproteinase |
| Zdroj: | Biochemical Journal |
| ISSN: | 1470-8728 |
| Popis: | The night and day cycle governs the circadian (24 hourly) rhythm of activity and rest in animals and humans. This is reflected in daily changes of the global gene expression pattern and metabolism, but also in the local physiology of various tissues. A central clock in the brain co-ordinates the rhythmic locomotion behaviour, as well as synchronizing various local oscillators, such as those found in the musculoskeletal system. It has become increasingly recognized that the internal molecular clocks in cells allow a tissue to anticipate the rhythmic changes in their local environment and the specific demands of that tissue. Consequently, the majority of the rhythmic clock controlled genes and pathways are tissue specific. The concept of the tissue-specific function of circadian clocks is further supported by the diverse musculoskeletal phenotypes in mice with deletions or mutations of various core clock components, ranging from increased bone mass, dwarfism, arthropathy, reduced muscle strength and tendon calcification. The present review summarizes the current understanding of the circadian clocks in muscle, bone, cartilage and tendon tissues, with particular focus on the evidence of circadian rhythms in tissue physiology, their entrainment mechanisms and disease links, and the tissue-specific clock target genes/pathways. Research in this area holds strong potential to advance our understanding of how circadian rhythms control the health and disease of the musculoskeletal tissues, which has major implications in diseases associated with advancing age. It could also have potential implications in sports performance and sports medicine. |
| Databáze: | OpenAIRE |
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